{"id":656,"date":"2026-06-03T05:43:08","date_gmt":"2026-06-03T05:43:08","guid":{"rendered":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/?page_id=656"},"modified":"2026-07-30T21:49:20","modified_gmt":"2026-07-30T21:49:20","slug":"evaluameco","status":"publish","type":"page","link":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/index.php\/evaluameco\/","title":{"rendered":"EVALUAMECO"},"content":{"rendered":"\n
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Drug Formulation, Technology Assessment, and Pharmacokinetics – EVALUAMECO<\/strong><\/p>\n<\/div>\n\n\n\n

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The characterization of drug release, absorption, distribution, metabolism, and excretion (ADME) has a major impact on drug development and provides rational criteria for selecting the most appropriate dosage form and route of administration. These factors are particularly important for compounds with bioavailability limitations and\/or high pharmacokinetic variability. The group works on the pre-formulation study of drugs and cosmetics, the characterization of in vitro release and absorption from their dosage forms, and the evaluation of the in vivo pharmacokinetic profile, integrating experimental data with pharmacokinetic\/pharmacodynamic (PK\/PD) and physiologically based pharmacokinetic (PBPK) modelling to support rational formulation and dosing decisions. <\/p>\n<\/div>\n<\/div>\n\n\n\n

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CV Prof. Matilde Merino Sanju\u00e1n<\/p>\n\n\n\n

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Matilde is a Full Professor of Pharmacy and Pharmaceutical Technology at the University of Valencia and Principal Investigator of the EVALUAMECO research group. Her research focuses on pharmacokinetic modelling and simulation to evaluate drug behaviour in the body and optimise dosing regimens. She also studies the factors affecting the equivalence of topical formulations administered through the skin.<\/p>\n\n\n\n

Over the last five years, she has participated in seven national and international research projects, serving as Principal Investigator in three of them, including several collaborative R&D&I projects with industry partners. She is the author of more than 100 publications in international scientific journals, as well as 26 books and book chapters.<\/p>\n<\/div>\n<\/div>\n\n\n\n

Research\u202fLines<\/strong>\u202f <\/p>\n\n\n\n

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Biopharmaceutical evaluation of drugs.<\/p>\n<\/div>\n\n\n\n

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Pharmacokinetic-pharmacodynamic modelling.<\/p>\n<\/div>\n\n\n\n

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Physiollogically-based pharmacokinetic modelling.<\/p>\n<\/div>\n\n\n\n

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Highlighted<\/strong> Funding<\/strong><\/p>\n\n\n\n

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Aproximaci\u00f3n farmacocin\u00e9tica, biofarmac\u00e9utica y tecnol\u00f3gica para la optimizaci\u00f3n de los tratamientos de enfermedades oculares inflamatorias y degenerativas. PID2022-142350OB-C22<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2023\u20132027. Virginia Merino Sanjuan.<\/em><\/p>\n\n\n\n

Evaluaci\u00f3n de la estructura interna de formulaciones t\u00f3picas semis\u00f3lidas. CIAICO\/2022\/170<\/strong>. Generalitat Valenciana (GVA). 2023-2025. Virginia Merino Sanjuan.<\/em><\/p>\n\n\n\n

Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines (ERAMET). 101137141<\/strong>. European Commission – Horizon RIA. 2024-2027.<\/em><\/p>\n\n\n\n

Estudio SePkLin: ensayo cl\u00ednico pragm\u00e1tico, multic\u00e9ntrico, aleatorizado y controlado en pacientes con Sepsis para evaluar la seguridad y eficacia de la dosificaci\u00f3n personalizada PK\/PD versus dosificaci\u00f3n est\u00e1ndar de Linezolid. ICI21\/00043<\/strong>. Instituto de Salud Carlos III. 2022-2025.<\/em><\/p>\n\n\n\n

Medicina Personalizada para la Optimizaci\u00f3n del Tratamiento Inmunomodulador en Pacientes con Uve\u00edtis (MedPOTIV). PI20\/00719<\/strong>. Instituto de Salud Carlos III.  2021-2023.<\/em><\/p>\n\n\n\n

Desarrollo de sistemas biodegradables intraoculares de antiVEGF para el tratamiento de la Degeneraci\u00f3n Macular Asociada a la Edad y a Retinopat\u00eda Diabetica (IMPLADEM). RTI2018-099597-B-I00<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2019-2022.<\/em><\/p>\n\n\n\n

Individualizaci\u00f3n posol\u00f3gica de Glucocerebrosidadasa en pacientes Gaucher Tipo I. GV\/2019\/167<\/strong>. Generalitat Valenciana (GVA). 2019-2020. Victor Mangas Sanjuan.<\/em><\/p>\n\n\n\n

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Highlighted Publications<\/strong><\/p>\n\n\n\n

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Reig-L\u00f3pez, J.; Cuquerella-Gilabert, M.; Zarzoso-Foj, J. et al<\/em>. Model-Based Design of Sustained-Release Formulations of Anti-TNF-\u03b1 Monoclonal Antibodies for Intravitreal Administration. Pharmaceutics<\/em>. 2026<\/strong>. 18(4), 445. https:\/\/doi.org\/10.3390\/pharmaceutics18040445<\/strong><\/a><\/p>\n\n\n\n

Ma\u00f1ez-Asensi, A.; Hern\u00e1ndez M.J.; Mangas-Sanju\u00e1n, V. et al<\/em>. Impact of shelf-life on the pharmaceutical equivalence assessment of a hydrocortisone semisolid W\/O emulsion: Evaluation of rheological, structural, and release properties.  European Journal of Pharmaceutical Sciences<\/em>. 2026<\/strong>. 221, 107535. 10.1016\/j.ejps.2026.107535<\/a><\/p>\n\n\n\n

Cuquerella-Gilabert, M.; De Carlo, A.; S\u00e1nchez Herrero, S. et al<\/em>. Leveraging Two-Stage \u03b4 Global Sensibility Analysis Method to Inform Parameter Estimation in PBPK Models. Pharmaceutical Statistics<\/em>. 2026<\/strong>. 25(2), e70082. https:\/\/doi.org\/10.1002\/pst.70082<\/strong><\/a><\/p>\n\n\n\n

Domenech-Monsell, I.; Alambiaga-Caravaca, A.M.; Bernat-Just, L. et al<\/em>. Development and Ex Vivo Evaluation of Famciclovir Ocular Inserts: Physicochemical Characterization and Biodistribution in Rabbit and Porcine Models.  Journal of Drug Delivery Science and Technology<\/em>. 2026<\/strong>. <\/strong>122, 108461. 10.1016\/j.jddst.2026.108461<\/a><\/p>\n\n\n\n

Valcuende-Rosique, A.; Esco\u00edn P\u00e9rez, C.; S\u00e1nchez-Alcaraz, A. et al<\/em>. Impact of Immune-Related Toxicity on Survival and Treatment Response in Non-Small Cell Lung Cancer Patients.  <\/strong>BMC Pulmonary Medicine<\/em>. 2026<\/strong>. 26(1), 135. 10.1186\/s12890-026-04185-3<\/a><\/p>\n\n\n\n

Cornejo-Uixeda, S.; Borr\u00e1s-Blasco, J.; Valcuende-Rosique, A. et al<\/em>. <\/strong>Dosing interval optimization and persistence with faricimab in age-related macular degeneration: An observational study in real-world clinical practice. Farmacia Hospitalaria<\/em>. 2026<\/strong>. 50(4), 269-272. 10.1016\/j.farma.2025.12.002<\/a><\/p>\n\n\n\n

Domenech-Monsell, I.M.; Alambiaga-Caravaca, A.M.; Bernat-Just, L. et al<\/em>. Innovative Famciclovir Eye Drop Formulations for Herpes Zoster Infections. Current Eye Research<\/em>. 2025<\/strong>. 50(6), 590-599. 10.1080\/02713683.2025.2472363<\/a><\/p>\n\n\n\n

Xu, Z.; Cuquerella-Gilabert, M.; Zarzoso-Foj, J. et al<\/em>. Comparison of dissolution profiles: 90 % confidence intervals of different f2 estimators using bootstrap methodology versus the Euclidean Distance of the Non-standardized Expected (EDNE) values. European Journal of Pharmaceutics and Biopharmaceutics<\/em>. 2025<\/strong>. 216, 114839. 10.1016\/j.ejpb.2025.114839<\/a><\/p>\n\n\n\n

Reig-L\u00f3pez, J.; Garc\u00eda-Otero, X.; Cuquerella-Gilabert, M. et al<\/em>. A physiologically based pharmacokinetic model to describe [89Zr]Zr-DFO-Adalimumab specific activity after intravitreal administration to rats with endotoxin-induced uveitis.  International Journal of Pharmaceutics<\/em>. 2025<\/strong>. 681, 125845. 10.1016\/j.ijpharm.2025.125845<\/a><\/p>\n\n\n\n

Zarzoso-Foj, J.; Cuquerella-Gilabert, M.; Merino-Sanjuan, M. et al<\/em>. Physiologically-Based Biopharmaceutics Modeling for Ibuprofen: Identifying Key Formulation Parameter and Virtual Bioequivalence Assessment. Pharmaceutics<\/em>. 2025<\/strong>. 17(4), 408. https:\/\/doi.org\/10.3390\/pharmaceutics17040408<\/strong><\/a><\/p>\n\n\n\n

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Prof. Virginia Merino Sanju\u00e1n <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Associate Prof. Victor Mangas Sanju\u00e1n <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dr. Marina Cuquerella Gilabert <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dr. Javier Reig L\u00f3pez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Andreu M\u00e1\u00f1ez Asensi <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Javier Zarzoso Foj <\/p>\n<\/div>\n<\/div>\n\n\n\n

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<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Drug Formulation, Technology Assessment, and Pharmacokinetics – EVALUAMECO The characterization of drug release, absorption, distribution, metabolism, and excretion (ADME) has a major impact on drug development and provides rational criteria for selecting the most appropriate dosage form and route of administration. These factors are particularly important for compounds with bioavailability limitations and\/or high pharmacokinetic variability. 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