{"id":671,"date":"2026-06-03T07:38:53","date_gmt":"2026-06-03T07:38:53","guid":{"rendered":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/?page_id=671"},"modified":"2026-09-01T07:48:56","modified_gmt":"2026-09-01T07:48:56","slug":"ginfar","status":"publish","type":"page","link":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/index.php\/ginfar\/","title":{"rendered":"GINFAR"},"content":{"rendered":"\n
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Inflammation Pharmacology –<\/strong> GINFAR<\/strong><\/p>\n<\/div>\n\n\n\n

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Our research focuses on the mechanisms underlying inflammatory and immune-mediated diseases, with particular emphasis on joint and skin disorders. We investigate the mediators, signalling pathways and protective mechanisms involved in disease progression to improve the understanding of pathogenesis and\u00a0identify\u00a0novel therapeutic targets. Our studies integrate in vivo,\u00a0in vitro\u00a0and translational approaches, using validated models of acute and chronic inflammation, rheumatoid arthritis,\u00a0osteoarthritis\u00a0and osteoporosis. We combine animal models with studies in cartilage explants, chondrocytes,\u00a0synoviocytes, osteoblasts, fibroblasts,\u00a0keratinocytes\u00a0and microvascular endothelial cells to analyse gene and protein expression, extracellular matrix remodelling, inflammatory\u00a0mediators\u00a0and intracellular signalling pathways. Our research also addresses cellular senescence and ageing-related mechanisms in chronic inflammatory diseases. A major focus is the therapeutic potential of mesenchymal stem cells and their extracellular vesicles as immunomodulatory, regenerative and cell communication agents, as well as their application as biomarkers for disease progression. In addition, we investigate adenosine-mediated pathways involved in skin inflammation and wound healing, particularly in vulnerable populations such as diabetic,\u00a0obese\u00a0and elderly patients. Our current activities also include international collaborative projects aimed at strengthening healthcare capacity, promoting the early diagnosis of chronic inflammatory diseases and reducing health inequalities through evidence-based strategies in resource-limited settings.\u00a0<\/p>\n<\/div>\n<\/div>\n\n\n\n

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CV Prof. M\u00aa Carmen Montesinos Mezquita<\/strong><\/p>\n\n\n\n

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M\u00aa Carmen Montesinos obtained her Pharmacy degree in 1990 and her PhD in 1994. Following a postdoctoral fellowship at New York University Medical\u00a0Center, she served as Assistant Research Scientist and Assistant Professor (1995\u20132004), investigating adenosine receptor signalling,\u00a0inflammation\u00a0and wound healing. Since 2005, she has been a Tenured Professor of Pharmacology at the University of Valencia. Her research focuses on inflammatory skin and joint diseases, with particular interest in adenosine signalling, extracellular\u00a0vesicles\u00a0and therapeutic strategies. She has authored 46 indexed publications (36 in Q1 journals), accumulating 3,178 citations and an H-index of 30. She is a member of several national and international research networks, including COST Action\u00a0BenBedPhar. She combines research with undergraduate and postgraduate\u00a0teaching, coordinating Pharmacology in the Pharmacy Degree and contributing to the Official\u00a0Master’s in Research\u00a0and Rational Use of Medicines. She has supervised 37 Bachelor’s, 17\u00a0Master’s\u00a0and 4 completed PhD theses.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Research\u202fLines<\/strong>\u202f <\/p>\n\n\n\n

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Inflammation and experimental models.<\/p>\n<\/div>\n\n\n\n

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Pathogenesis of articular damage.<\/p>\n<\/div>\n\n\n\n

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Cellular stress response.<\/p>\n<\/div>\n\n\n\n

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Cutaneous inflammation and regeneration.<\/p>\n<\/div>\n\n\n\n

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Global Health and Health Equity in Chronic Inflammatory Diseases.<\/p>\n<\/div>\n\n\n\n

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Rational use of medicines and Pharmaceutical care.<\/p>\n<\/div>\n\n\n\n

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Highlighted<\/strong> Funding<\/strong><\/p>\n\n\n\n

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Promoci\u00f3n del diagn\u00f3stico precoz de articulopat\u00edas inflamatorias y esclerodermia en atenci\u00f3n primaria rural mediante formaci\u00f3n especializada y ecograf\u00eda port\u00e1til. Universitat de Val\u00e8ncia. 2026-2027. M\u00aa Carmen Montesinos Mezquita<\/em>. <\/p>\n\n\n\n

Estrategias de diagn\u00f3stico y tratamiento en enfermedades inflamatorias cr\u00f3nicas articulares y de la piel. PID2021-124890OB-I00<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2022-2026. M\u00aa Carmen Montesinos Mezquita.<\/em> <\/p>\n\n\n\n

Nuevos Enfoques Diagn\u00f3sticos y Terap\u00e9uticos en Artritis psori\u00e1sica. CIGE\/2024\/101<\/strong>. <\/strong>Conselleria<\/em> <\/em><\/strong>d\u2019Educaci\u00f3, Cultura i Universitats. 2025-2027. M\u00aa Carmen Carceller Zazo<\/em>. <\/p>\n\n\n\n

Piel y Derechos Humanos: Sensibilizaci\u00f3n sobre Psoriasis, Artritis Psori\u00e1sica y Salud Global. Ayudas C\u00e1tedra UNESCO para acciones de Educaci\u00f3n para el Desarrollo, Ciudadan\u00eda Global y Sensibilizaci\u00f3n. Universitat de Val\u00e8ncia. 2025\u20132026. M\u00aa Carmen Carceller Zazo.<\/em> <\/p>\n\n\n\n

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Highlighted<\/strong> Publications<\/strong><\/p>\n\n\n\n

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Guti\u00e9rrez-Igual S.; Lucas-Dom\u00ednguez R.; Sendra-Lillo J. et al<\/em>. Comparative analysis of Pharmaceutical Care practice in rural and urban community pharmacies in Valencia, Spain: a quasi-experimental study. BMC Health Services Research<\/em>. 2026<\/strong>. doi: https:\/\/doi.org\/10.1186\/s12913-026-14739-0<\/a>  <\/p>\n\n\n\n

Guti\u00e9rrez-Igual S.; Lucas-Dom\u00ednguez R.; Sendra-Lillo J.; et al<\/em>. Impact of pharmacist-led interventions in identifying and resolving drug related problems and potentially inappropriate prescriptions among rural patients: A pilot study. Exploratory Research in Clinical and Social Pharmacy<\/em>. 2024<\/strong>. 16, 100536. https:\/\/doi.org\/10.1016\/j.rcsop.2024.100536<\/a>  <\/p>\n\n\n\n

Guti\u00e9rrez-Igual S.; Lucas-Dom\u00ednguez R.; Romero Crespo I. et al<\/em>. An\u00e1lisis y categorizaci\u00f3n de las consultas farmacoterap\u00e9uticas recibidas en un Centro de Informaci\u00f3n de Medicamentos de Valencia. Analysis and categorization of pharmacotherapeutic queries received at a Valencia Drug Information Center. Farmac\u00e9uticos Comunitarios<\/em>. 2024<\/strong>. 16, 4,5-11. https:\/\/doi.org\/10.33620\/FC.2173-9218.(2024).24<\/a>  <\/p>\n\n\n\n

Catal\u00e1n\u00a0L.;\u00a0Carceller\u00a0M.C.;\u00a0Terencio\u00a0M.C.;\u00a0et al<\/em>.\u00a0Osteostatin\u00a0Mitigates Gouty Arthritis through the Inhibition of Caspase-1 Activation and Upregulation of Nrf2 Expression.\u00a0International Journal of Molecular Sciences<\/em>.\u00a02024<\/strong>.\u00a025,\u00a05,2752.\u00a0https:\/\/doi.org\/10.3390\/ijms25052752<\/a><\/p>\n\n\n\n

Mar\u00edn-Castej\u00f3n A.; Marco-Bonilla M.; Terencio M.C.; et al<\/em>. Adenosine A2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia. Biomedicine &\u202fPharmacotherapy<\/em>. 2024. <\/strong>173, 116401. https:\/\/doi.org\/10.1016\/j.biopha.2024.116401<\/a>  <\/p>\n\n\n\n

L\u00f3pez-Riera M.; Ortega R.; Hueso L.; et al<\/em>. Activation of the Constitutive Androstane Receptor Inhibits Leukocyte Adhesiveness to Dysfunctional Endothelium. International Journal of Molecular Sciences<\/em>. 2021<\/strong>. 22, 17, 9267. https:\/\/doi.org\/10.3390\/ijms22179267<\/a>  <\/p>\n\n\n\n

Valls M.D.; Soldado M., Arasa J. et al<\/em>. Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A<\/sub>\u202fReceptors. Frontiers in Pharmacology<\/em>. 2021.<\/strong> 12, 654104. https:\/\/doi.org\/10.3389\/fphar.2021.654104<\/a>  <\/p>\n\n\n\n

Carceller\u00a0M.C.;\u00a0Guill\u00e9n\u00a0M.I.;\u00a0Gil M.L.\u00a0et al<\/em>. Extracellular Vesicles Do Not Mediate the Anti-Inflammatory Actions of Mouse-Derived Adipose Tissue Mesenchymal Stem Cells\u00a0Secretome.\u00a0International Journal of Molecular Sciences<\/em>.\u00a02021<\/strong>.\u00a022,\u00a03,\u00a01375.\u00a0https:\/\/doi.org\/10.3390\/ijms22031375<\/a>\u00a0\u00a0<\/p>\n\n\n\n

Sanz-Gil R.; Pellicer A.; Montesinos M.C.; et al<\/em>. Improved effectiveness from individualized dosing of self-administered biologics for the treatment of moderate-to-severe psoriasis: a 5-year retrospective chart review from a Spanish University Hospital. Journal of Dermatological Treatment.<\/em> 2020<\/strong>. 31, 4, 370-377. https:\/\/doi.org\/10.1080\/09546634.2019.1602246<\/a>  <\/p>\n\n\n\n

Arasa\u00a0J.;\u00a0Terencio\u00a0M.C.;\u00a0Andr\u00e9s R.M.\u00a0et a<\/em>l.\u00a0Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory\u00a0Activation of Macrophages.\u00a0Frontiers in Immunology.<\/em>\u00a02019<\/strong>.\u00a010,536.\u00a0https:\/\/doi.org\/10.3389\/fimmu.2019.00536<\/a><\/p>\n\n\n\n

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See more<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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Prof. M\u00aa Luisa Ferr\u00e1ndiz Manglano <\/p>\n\n\n\n

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Prof. M\u00aa Antonia Noguera Romero <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Isabel Garc\u00eda Arnandis\u00a0<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. M\u00aa Carmen Carceller Zazo\u00a0<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Anastasia Riske <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Mohammad Sudqi Hamad Mohammad <\/p>\n<\/div>\n<\/div>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Inflammation Pharmacology – GINFAR Our research focuses on the mechanisms underlying inflammatory and immune-mediated diseases, with particular emphasis on joint and skin disorders. We investigate the mediators, signalling pathways and protective mechanisms involved in disease progression to improve the understanding of pathogenesis and\u00a0identify\u00a0novel therapeutic targets. Our studies integrate in vivo,\u00a0in vitro\u00a0and translational approaches, using validated […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-671","page","type-page","status-publish","hentry"],"yoast_head":"\nGINFAR – Instituto Interuniversitario de Reconocimiento Molecular y Desarollo Tecnol\u00f3gico<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/idm-instituto.webs.upv.es\/wordpress\/index.php\/ginfar\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GINFAR – Instituto Interuniversitario de Reconocimiento Molecular y Desarollo Tecnol\u00f3gico\" \/>\n<meta property=\"og:description\" content=\"Inflammation Pharmacology – GINFAR Our research focuses on the mechanisms underlying inflammatory and immune-mediated diseases, with particular emphasis on joint and skin disorders. 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