{"id":682,"date":"2026-06-03T08:08:15","date_gmt":"2026-06-03T08:08:15","guid":{"rendered":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/?page_id=682"},"modified":"2026-10-15T12:13:05","modified_gmt":"2026-10-15T12:13:05","slug":"modelic","status":"publish","type":"page","link":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/index.php\/modelic\/","title":{"rendered":"MODeLiC"},"content":{"rendered":"\n
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Organic Materials for Detection and Controlled Release – MODeLiC<\/strong><\/p>\n<\/div>\n\n\n\n

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Research focuses on the synthesis and evaluation of colorimetric and fluorometric chemical sensors specifically designed for biomedical applications and personal safety. This includes assessing the sensing performance of newly developed compounds in cellular environments to monitor biologically relevant processes and detect disease-related biomarkers. In parallel, the group has developed highly selective, user-friendly sensors for the in situ detection of chemical submission drugs, such as GHB, in alcoholic beverages and soft drinks. These portable detection systems are designed to be safe, affordable, and accessible to non-specialist users, providing rapid and reliable results in real-world social settings. <\/p>\n\n\n\n

A second major research line is the design of smart nanomaterials for controlled drug delivery to improve the treatment of diseases such as osteoporosis, solid tumors, and inflammatory bowel disease. These systems incorporate molecular gates activated by external stimuli, enabling site-specific and on-demand drug release while reducing side effects. By combining supramolecular chemistry, nanotechnology, and biomedicine, the group develops multifunctional organic\u2013inorganic hybrid materials with theranostic capabilities, integrating disease diagnosis, targeted therapy, and real-time treatment monitoring within a single platform. <\/p>\n<\/div>\n<\/div>\n\n\n\n

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CV Prof. Pablo Gavi\u00f1a Costero<\/strong><\/p>\n\n\n\n

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He obtained a BSc in Chemistry (1989) and a PhD in Chemistry (1994) from the University of Valencia. Following a postdoctoral fellowship (1995\u20131997) with Prof. Jean-Pierre Sauvage (Nobel Laureate in Chemistry, 2016) at Universit\u00e9 Louis Pasteur, Strasbourg, he returned to the Institute of Molecular Science (ICMol), where he worked on molecular motors, metallosupramolecular architectures, and luminescent metal complexes. He joined idm in 2011, became Full Professor of Organic Chemistry in 2021, and has led the MODeLiC research group since 2022. His research focuses on chemosensors, molecular probes, and gated mesoporous silica nanomaterials for sensing and drug delivery. He has authored 105 peer-reviewed articles and four book chapters (h-index 30; ~4,000 citations), participated in 36 competitive research projects (11 as PI\/co-PI), holds seven patents, co-founded Optical Sens SL in 2024, and has supervised 11 PhD and 10 MSc theses.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Research\u202fLines<\/strong>\u202f <\/p>\n\n\n\n

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Chemosensors and Smart materials for the detection of chemical species of interest.<\/p>\n<\/div>\n\n\n\n

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Functionalized porous nanomaterials for the controlled release of drugs and\/or fluorophores.<\/p>\n<\/div>\n\n\n\n

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Highlighted<\/strong> Funding<\/strong><\/p>\n\n\n\n

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Kits para detecci\u00f3n r\u00e1pida de GHB en bebidas, saliva y orina. Evidencia e impacto de las agresiones por sumisi\u00f3n qu\u00edmica en la comunidad valenciana (VSAFE). PND2025-I044<\/strong>. Ministerio de Sanidad. 2026-2027. Pablo Gavi\u00f1a<\/em><\/p>\n\n\n\n

Quimiosensores y materiales inteligentes para la detecci\u00f3n de drogas il\u00edcitas y liberaci\u00f3n de drogas dirigida a tumores solidos (SMADDS). PID2024-155683OB-C42<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2025-2028. <\/em>Pablo Gavi\u00f1a, Margarita Parra<\/em><\/p>\n\n\n\n

Dispositius per a detectar la submissi\u00f3 qu\u00edmica. UV-INV-PROVAL25-3960176<\/strong>. <\/strong>Universitat de Valencia (UV)<\/em>. <\/em>2025-2027<\/em>. Salvador Gil<\/em><\/p>\n\n\n\n

Nanosistemas de liberaci\u00f3n controlada para la detecci\u00f3n y tratamiento de tumores pip\u00f3xicos (NANOHIPOX). CIAICO\/2022\/146<\/strong>. Generalitat Valenciana (GVA). 2023-2025. Pablo Gavi\u00f1a, Margarita Parra<\/em><\/p>\n\n\n\n

Desarrollo de kits basados en sondas moleculares para la detecci\u00f3n de drogas de sumisi\u00f3n qu\u00edmica (NOSUMPROBES). PDC2022-133576-C22<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2024-2025. Pablo Gavi\u00f1a, Ram\u00f3n Mart\u00ednez<\/em><\/p>\n\n\n\n

Quimiosensores y materiales inteligentes para la detecci\u00f3n de drogas y tratamiento\/imagen de trumores hip\u00f3xicos (HYDRUGSENS). PID2021-126304OB-C42<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2022-2025. Pablo Gavi\u00f1a, Margarita Parra<\/em><\/p>\n\n\n\n

Desarrollo de una sonda molecular para detecci\u00f3n de la droga de sumisi\u00f3n qu\u00edmica GHB (NOSUQUI). UV-INV_PROVAL21-1871796<\/strong>. Universitat de Valencia. 2022-2023. Ana M. Costero, Pablo Gavi\u00f1a<\/em><\/p>\n\n\n\n

Dise\u00f1o y evaluaci\u00f3n de un \u201ckit personal\u201d para prevenir las agresiones sexuales por sumisi\u00f3n qu\u00edmica (NOSUM). PND2020-I040<\/strong>. Ministerio de Sanidad. 2021-2022. Pablo Gavi\u00f1a<\/em><\/p>\n\n\n\n

Materiales inteligentes para la detecci\u00f3n de drogas de abuso y biomarcadores (BIOMEDCOM). RTI2018-100910-B-C42<\/strong>. Agencia Estatal de Investigaci\u00f3n (AEI). 2019-2021. Ana M. Costero, Pablo Gavi\u00f1a<\/em><\/p>\n\n\n\n

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Highlighted Publications<\/strong><\/p>\n\n\n\n

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Roig-Rubio, J.; Hern\u00e1ndez-Contreras, J.; Parra, M. et al<\/em>. A \u201cturn-on\u201d fluorogenic probe for the rapid and on-site detection of synthetic cathinones, ketamine and scopolamine in water and beverages. Sensing and Bio-Sensing Research<\/em>. 2026<\/strong>. 51, 100987. https:\/\/doi.org\/10.1016\/j.sbsr.2026.100987<\/a> <\/p>\n\n\n\n

Rodrigo-Mart\u00ednez, P.; Barros, M.; Terencio, M.C. et al.<\/em> Mesoporous silica nanoparticles with an azobenzene gatekeeper as hypoxia-responsive nanocarriers for targeted doxorubicin delivery. Drug Delivery and Translational Research<\/em>. 2026<\/strong>. 16, 5, 1423-1434. https:\/\/doi.org\/10.1007\/s13346-025-01950-5<\/a> <\/p>\n\n\n\n

Barros, M.; S\u00e1ez, J.A.; Arroyo, P. et al<\/em>. Nitroreductase-responsive gated mesoporous silica nanocarriers for hypoxia-targeted drug delivery. International Journal of Pharmaceutics<\/em>. 2025<\/strong>. 672, 125326. https:\/\/doi.org\/10.1016\/j.ijpharm.2025.125326<\/a><\/p>\n\n\n\n

Barros, M.; Arroyo, P.; S\u00e1ez, J.A. et al.<\/em> Push-pull fluorophores based on NHS esters of bithiophene for labelling of biomolecules containing primary amines. Royal Society Open Science<\/em>. 2025<\/strong>. 12, 241816. https:\/\/doi.org\/10.1098\/rsos.241816<\/a><\/p>\n\n\n\n

Hern\u00e1ndez-Contreras, J.; Roig-Rubio, J.; Parra, M. et al.<\/em> Silica-based optical chemosensors for rapid and reliable on-site detection of gamma-hydroxybutyrate in beverages and oral fluids. Microchimica Acta<\/em>. 2025<\/strong>. 192, 275. https:\/\/doi.org\/10.1007\/s00604-025-07134-9<\/a><\/p>\n\n\n\n

Hern\u00e1ndez-Contreras, J.; Roig-Rubio, J.; Parra, M. et al.<\/em> Green and real-time detection of GHB in soft drinks and alcoholic beverages using an eco-friendly cellulose paper-based fluorescent probe. Sensing and Bio-Sensing Research. 2024<\/strong>. 46, 100691. https:\/\/doi.org\/10.1016\/j.sbsr.2024.100691<\/a><\/p>\n\n\n\n

Hern\u00e1ndez-Contreras, J.; Madrigal P.; Arroyo, P. et al.<\/em> Optical detection of scopolamine and ketamine with a BODIPY-Phen conjugate and Cu(II). Dyes and Pigments<\/em>. 2024<\/strong>. 221, 111806. https:\/\/doi.org\/10.1016\/j.dyepig.2023.111806<\/a><\/p>\n\n\n\n

Mart\u00ed, A. Arroyo, P. Gavi\u00f1a, P. et al<\/em>. Gold nanoparticles as monoanion sensors through modified electrophilicity. Colorants<\/em>. 2023<\/strong>. 2, 491-600. https:\/\/doi.org\/10.3390\/colorants2040030<\/a><\/p>\n\n\n\n

Hern\u00e1ndez-Contreras, J.; Parra, M., Gil, S. et al<\/em>. Colorimetric and fluorescent detection of synthetic cathinones in oral fluid with meso-aryl BODIPYs and Cu(II). RSC Advances<\/em>. 2022<\/strong>. 12, 28580-28585. https:\/\/doi.org\/10.1039\/d2ra05188e<\/a><\/p>\n\n\n\n

Rodr\u00edguez-Nu\u00e9valos, S. Costero, A.M.; Parra, M. et al<\/em>. Colorimetric and fluorescent BODIPY-hydrazone probes for the detection of \u03b3-hydroxybutyric acid (GHB) and cathinones. Dyes and Pigments<\/em>. 2022<\/strong>. 207, 110757. https:\/\/doi.org\/10.1016\/j.dyepig.2022.110757<\/a><\/p>\n\n\n\n

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Prof. Margarita Parra<\/p>\n\n\n\n

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Prof. Salvador Gil Grau <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Pau Arroyo M\u00e1\u00f1ez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Jose Antonio S\u00e1ez Cases <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Mar\u00eda Carmen Mart\u00ednez Bisbal <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Carmen Coll Merino <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Daniel Gavi\u00f1a Rueda<\/p>\n\n\n\n

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Jordi Roig Rubio <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Carlos Herrera Saiz <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Enrique Terol Ortol\u00e1<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Agustina Altuna <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Martina Beviglia Emilce <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Organic Materials for Detection and Controlled Release – MODeLiC Research focuses on the synthesis and evaluation of colorimetric and fluorometric chemical sensors specifically designed for biomedical applications and personal safety. This includes assessing the sensing performance of newly developed compounds in cellular environments to monitor biologically relevant processes and detect disease-related biomarkers. 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