{"id":685,"date":"2026-06-03T08:42:30","date_gmt":"2026-06-03T08:42:30","guid":{"rendered":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/?page_id=685"},"modified":"2026-07-30T22:24:43","modified_gmt":"2026-07-30T22:24:43","slug":"nanosens","status":"publish","type":"page","link":"https:\/\/idm-instituto.webs.upv.es\/wordpress\/index.php\/nanosens\/","title":{"rendered":"NANOSENS"},"content":{"rendered":"\n
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Nanomaterials and Sensors – NANOSENS<\/strong><\/p>\n<\/div>\n\n\n\n

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Our research group focuses on the design and development of advanced functional materials for applications in biomedicine, agri-food, and environmental fields.<\/p>\n\n\n\n

A central line of research involves the development of controlled release nanoparticles such as mesoporous materials containing molecular gates, lipid nanoparticles, liposomes, giant unilamellar vesicles, metallic nanoparticles, and related nanosystems. These platforms enable the precise delivery of drugs, genetic material, including DNA and RNA, and antimicrobial agents.<\/p>\n\n\n\n

In addition, the group develops advanced nanosystems for chemical communication, nanomotors, and smart materials capable of responding to specific chemical signals. These systems enable more efficient and controlled release of active compounds, while providing a basis for understanding interactions and communication processes between nanoparticles and other synthetic or biological entities.<\/p>\n\n\n\n

In parallel, the group develops molecular probes, nanosensors, and biosensors for electrochemical, chromogenic, and fluorogenic detection of cells, biomarkers, ions, metabolites, and pathogens, with applications in diagnosis, environmental monitoring, food safety, and point-of-care testing.<\/p>\n\n\n\n

Another recent key area is the development of molecular cages for biological applications, creating encapsulation and recognition systems for the selective delivery of drugs and the detection of biomarkers, with particular relevance in oncology and diagnosis.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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CV Prof. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez<\/strong><\/p>\n\n\n\n

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Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez is Professor of Inorganic Chemistry at UPV, Director of the Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), and former Scientific Director of CIBER-BBN from 2015 to 2024. He coordinates joint research units in nanomedicine and sensors with La Fe Hospital and the Pr\u00edncipe Felipe Research Center. With over 30 years of experience, his research has focused on molecular probes, chemical sensors, chromo-fluorogenic sensing and controlled-release systems for biomedical applications. He has coordinated 188 national and European projects, participates in 9 European projects, including the ERC Advanced Grant EDISON, and has collaborated in more than 50 industry-linked projects. He has published more than 643 articles, holds 50 patents, and co-founded three spin-offs. His awards include the RSEQ Research Excellence Award, King Jaume I Award, and Juan de la Cierva National Research Award.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Research\u202fLines<\/strong>\u202f <\/p>\n\n\n\n

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Gated mesoporous silica for controlled release.<\/p>\n<\/div>\n\n\n\n

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Lipid nanoparticles and RNA\/mRNA delivery systems.<\/p>\n<\/div>\n\n\n\n

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Molecular cages and supramolecular systems for biological applications.<\/p>\n<\/div>\n\n\n\n

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Molecular probes as optical chemosensors.<\/p>\n<\/div>\n\n\n\n

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Nanosensors, biosensors and metabolomics for diagnosis, prognosis and point-of-care testing.<\/p>\n<\/div>\n\n\n\n

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Self-propelled and stimuli-responsive nanomotors.<\/p>\n<\/div>\n\n\n\n

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Chemical communication and artificial cell-like systems.<\/p>\n<\/div>\n\n\n\n

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Smart antimicrobial and anti-biofilm nanotechnology.<\/p>\n<\/div>\n\n\n\n

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Highlighted Funding<\/strong><\/p>\n\n\n\n

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Smart Implants for Life Enrichment (SMILE). 101136376.<\/strong> European Commission – Horizon RIA. 2025\u20132029. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

A Novel Immunotherapy for Infectious Diseases (NANOBICAR). 101186252. <\/strong>European Commission – Horizon EIC. 2025\u20132028. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

Specific Universal Immunotherapeutic Method for Cancer (ONCOFLAG). 101248697.<\/strong> European Commission – Horizon ERC Proof of Concept. 2025\u20132027. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez<\/em>.<\/p>\n\n\n\n

European Rare Diseases Research Alliance (ERDERA). 101156595.<\/strong> European Commission – Horizon COFUND. 2024\u20132031. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

Postdoctoral Program in Biomedicine and Health Sciences (ARISTOS). 101081334.<\/strong> Horizon TMA MSCA Cofund. 2023\u20132028. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

Engineered Particles for Chemical Communication (EDISON). 101052997.<\/strong> European Commission – Horizon ERC Advanced. 2022\u20132027. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

Development of photonic multi-sensing systems based on molecular-gates biorecognition and plasmonic sensors (PHOTONGATE). 101093042.<\/strong> European Commission – Horizon RIA. 2022\u20132026. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

Immunological incompatibility as a basis for cancer curing and vaccination (ULISES). 899708.<\/strong> European Commission – Horizon 2020 FET Open. 2020\u20132024. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

Safety testing in the life cycle of nanotechnology-enabled medical technologies for health (SAFE-N-MEDTECH). 814607.<\/strong> European Commission – Horizon 2020 IA. 2019\u20132023. Ram\u00f3n Mart\u00ednez M\u00e1\u00f1ez.<\/em><\/p>\n\n\n\n

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Highlighted Publications<\/strong><\/p>\n\n\n\n

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Mont\u00e0-Gonz\u00e1lez, G.; Garrido, E.; Climent, E. et al.<\/em> Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection. Angewandte Chemie International Edition.<\/em> 2026.<\/strong> 65, e23575. https:\/\/doi.org\/10.1002\/anie.202523575<\/a><\/p>\n\n\n\n

Torres-Mesado, A.; Caballos, I.; L\u00f3pez-Palacios, A. et al.<\/em> Test Strips Based on Gated Nanoporous Anodic Alumina for the Rapid and Accurate Detection of Pseudomonas aeruginosa<\/em> in Clinical Samples. Analytical Chemistry.<\/em> 2026.<\/strong> 98, 11807\u201311821. https:\/\/doi.org\/10.1021\/acs.analchem.5c07621<\/a><\/p>\n\n\n\n

Mart\u00ednez-Latorre, J.; Soriano-Teruel, P. M.; Candela-Noguera, V. et al.<\/em> Harnessing Pre-Existing Measles Immunity: mRNA-Lipid Nanoparticle-Mediated Measles Hemagglutinin Expression Boosts Antitumor CD8\u207a T Cell Responses. Signal Transduction and Targeted Therapy.<\/em> 2026.<\/strong> 11, 164.
https:\/\/doi.org\/10.1038\/s41392-026-02716-2<\/a> <\/p>\n\n\n\n

Ortu\u00f1o-Bernal, A.; Clara-Trujillo, S.; Lucena-S\u00e1nchez, E. et al.<\/em> Bi-Functional Topospecific Nanoparticles to Promote Immune-Tumor Cell Engagement as a New Immunotherapeutic Strategy. Advanced Materials.<\/em> 2025.<\/strong> e18838.
https:\/\/doi.org\/10.1002\/adma.202418838<\/a> <\/p>\n\n\n\n

Esteve-Moreno, J. J.; Escudero, A.; Silvestre, O. F. et al.<\/em> Bioorthogonal Photoactivation of 2-Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars. Advanced Materials.<\/em> 2025.<\/strong> e10898.
https:\/\/doi.org\/10.1002\/adma.202510898<\/a> <\/p>\n\n\n\n

Escudero, A.; Hicke, F. J.; Lucena-S\u00e1nchez, E. et al.<\/em> Glucose-Fueled Gated Nanomotors: Enhancing In Vivo Anticancer Efficacy via Deep Drug Penetration into Tumors. ACS Nano.<\/em> 2025.<\/strong> 19, 20932\u201320955.
https:\/\/doi.org\/10.1021\/acsnano.5c03799<\/a><\/p>\n\n\n\n

Rojas-V\u00e1zquez, S.; Lozano-Torres, B.; Garc\u00eda-Fern\u00e1ndez, A. et al.<\/em> A Renal Clearable Fluorogenic Probe for In Vivo \u03b2-Galactosidase Activity Detection During Aging and Senolysis. Nature Communications.<\/em> 2024.<\/strong> 15, 775.
https:\/\/doi.org\/10.1038\/s41467-024-44903-1<\/a> <\/p>\n\n\n\n

Llopis-Lorente, A.; Shao, J.; Ventura, J. et al.<\/em> Spatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures. ACS Central Science.<\/em> 2024.<\/strong> 10, 1619\u20131628.
https:\/\/doi.org\/10.1021\/acscentsci.4c00702<\/a> <\/p>\n\n\n\n

\u017diemyt\u0117, M.; Escudero, A.; D\u00edez, P. et al.<\/em> Ficin\u2013Cyclodextrin-Based Docking Nanoarchitectonics of Self-Propelled Nanomotors for Bacterial Biofilm Eradication. Chemistry of Materials.<\/em> 2023.<\/strong> 35, 4412\u20134426.
https:\/\/doi.org\/10.1021\/acs.chemmater.3c00587<\/a><\/p>\n\n\n\n

Lozano-Torres, B.; Galiana, I.; Rovira, M. et al.<\/em> An OFF\u2013ON Two-Photon Fluorescent Probe for Tracking Cell Senescence In Vivo. Journal of the American Chemical Society.<\/em> 2017.<\/strong> 139, 8808\u20138811.
https:\/\/doi.org\/10.1021\/jacs.7b04985<\/a> <\/p>\n\n\n\n

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Prof. M\u00aa Dolores Marcos Mart\u00ednez\u200b <\/p>\n<\/div>\n\n\n\n

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Prof. Elena Aznar Gimeno\u200b <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. F\u00e9lix\u202fSancen\u00f3n\u202fGalarza\u200b <\/p>\n<\/div>\n\n\n\n

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Prof. Jose Ram\u00f3n Murgu\u00eda Ib\u00e1\u00f1ez\u200b <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Andrea Bernardos Bau\u200b <\/p>\n<\/div>\n\n\n\n

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Prof. Vicente Mart\u00ed\u202f Centelles\u200b <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Prof. Luis \u00c1ngel Villaescusa Alonso\u200b <\/p>\n<\/div>\n\n\n\n

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Prof. Estela Climent Terol <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dr. Antoni Llopis Lorente <\/p>\n<\/div>\n\n\n\n

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Dra. Paula D\u00edez S\u00e1nchez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dra. Alba Garc\u00eda Fern\u00e1ndez <\/p>\n<\/div>\n\n\n\n

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Dra. Sandra Pradana L\u00f3pez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dra. Ana M\u00aa. P\u00e9rez Calabuig <\/p>\n<\/div>\n\n\n\n

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Dra. Carla Arnau del Valle <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dr. Alfredo L\u00f3pez Olvera <\/p>\n<\/div>\n\n\n\n

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Dra. Erika Pineda Ram\u00edrez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dra. Marcia Dom\u00ednguez Rodr\u00edguez <\/p>\n<\/div>\n\n\n\n

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Dra. Eva Mar\u00eda Garrido Garc\u00eda <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dra. Serena Medaglia <\/p>\n<\/div>\n\n\n\n

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Dr. Giovanni Mont\u00e1 Gonz\u00e1lez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dr. Vicente Candela Noguera <\/p>\n<\/div>\n\n\n\n

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Dra. Sandra Clara Trujillo <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Dra. Andrea Escudero Noguera <\/p>\n<\/div>\n\n\n\n

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Dra. Paula Mar\u00eda Soriano Teruel <\/p>\n<\/div>\n<\/div>\n\n\n\n

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 Dr. Javier Mart\u00ednez Latorre<\/p>\n<\/div>\n\n\n\n

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\u00c1ngela Morell\u00e1 Aucejo <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Miguel Reyes Torres <\/p>\n<\/div>\n\n\n\n

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V\u00edctor Sanz \u00c1lvarez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Jordi Ventura Cobos <\/p>\n<\/div>\n\n\n\n

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Jessie Garc\u00eda Fleitas<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Guillermo Hern\u00e1ndez Sig\u00fcenza <\/p>\n<\/div>\n\n\n\n

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Francisco Javier Hicke Garc\u00eda <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Carolina L\u00f3pez Benet <\/p>\n<\/div>\n\n\n\n

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Roc\u00edo L\u00f3pez Lima <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Guillermo Luciano Fiorini <\/p>\n<\/div>\n\n\n\n

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Rafael Napole\u00f3n Guzm\u00e1n Ferreira <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Adriana Gabriela Camino de Prinzio <\/p>\n<\/div>\n\n\n\n

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Eva Caud\u00e9 Rubicos <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Lara Moll\u00e1 Guerola <\/p>\n<\/div>\n\n\n\n

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Pablo Jos\u00e9 Alarc\u00f3n Meseguer <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Eduardo Ortiz G\u00f3mez <\/p>\n<\/div>\n\n\n\n

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Mar\u00eda Miralles Buleo <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Laura Mart\u00ednez Forner <\/p>\n<\/div>\n\n\n\n

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Aritz Mart\u00ednez Rodr\u00edguez <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Carla Beseler Le\u00f3n <\/p>\n<\/div>\n\n\n\n

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Carolina Alventosa D\u00edaz <\/p>\n<\/div>\n<\/div>\n\n\n\n

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David Azor\u00edn Soriano <\/p>\n<\/div>\n\n\n\n

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Karlamercy de la Caridad S\u00e1nchez Llerena <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Isabel Montoya M\u00e9ndez <\/p>\n<\/div>\n\n\n\n

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Alba Amparo Ortu\u00f1o Bernal <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Faustino Palomo Matarranz <\/p>\n<\/div>\n\n\n\n

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Noelia P\u00e9rez Ventura <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Andrea Torres Mesado <\/p>\n<\/div>\n\n\n\n

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Sof\u00eda Dom\u00e9nech Dauder <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Faustino Palomo Matarranz <\/p>\n<\/div>\n\n\n\n

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Noelia P\u00e9rez Ventura <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Andrea Torres Mesado <\/p>\n<\/div>\n\n\n\n

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Sof\u00eda Dom\u00e9nech Dauder <\/p>\n<\/div>\n<\/div>\n\n\n\n

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Pedro Javier Vargas Machado <\/p>\n<\/div>\n\n\n\n

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Yoel Esteve S\u00e1nchez <\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Nanomaterials and Sensors – NANOSENS Our research group focuses on the design and development of advanced functional materials for applications in biomedicine, agri-food, and environmental fields. A central line of research involves the development of controlled release nanoparticles such as mesoporous materials containing molecular gates, lipid nanoparticles, liposomes, giant unilamellar vesicles, metallic nanoparticles, and related […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-685","page","type-page","status-publish","hentry"],"yoast_head":"\nNANOSENS – Instituto Interuniversitario de Reconocimiento Molecular y Desarollo Tecnol\u00f3gico<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/idm-instituto.webs.upv.es\/wordpress\/index.php\/nanosens\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NANOSENS – Instituto Interuniversitario de Reconocimiento Molecular y Desarollo Tecnol\u00f3gico\" \/>\n<meta property=\"og:description\" content=\"Nanomaterials and Sensors – NANOSENS Our research group focuses on the design and development of advanced functional materials for applications in biomedicine, agri-food, and environmental fields. 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