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Projects

  • 2024
  • 2023

Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines (ERAMET). 101137141. European Commission – Horizon 2020 RIA. 2024–2027. Virginia Merino.


Aproximación farmacocinética, biofarmacéutica y tecnológica para la optimización de los tratamientos de enfermedades oculares inflamatorias y degenerativas. PID2022-142350OB-C22. Agencia Estatal de Investigación (AEI). 2023–2027. Virginia Merino.


Evaluación de la estructura interna de formulaciones tópicas semisólidas. CIAICO/2022/170. Generalitat Valenciana – CIAICO. 2023–2025. Virginia Merino Sanjuán.


Publications

  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020

Gledys Reynaldo‑Fernandez, Leyanis Rodriguez‑Vera, Daniel Amaro, Joaquin Solozábal, Jorge Duconge, Victor Mangas‑Sanjuan, Iñaki F. Troconiz, Francine Johansson Azeredo, Valvanera Vozmediano

Forecasting the Biological Effect of PEGylated-rHuEPO Candidates in Chronic Kidney Disease Patients using a Middle-out Translation Approach

Pharmaceutical Research · DOI: 10.1007/s11095-025-04013-z


Karine Rodriguez‑Fernandez, José David Gómez‑Mantilla, Suneet Shukla, Victor Mangas‑Sanjuán, Sheila Annie Peters

Solubility-Limited Absorption Identified by a Simplified PBPK Model for the Prediction of Positive Food Effect for BCS II/IV Drugs

Clinical Pharmacokinetics · DOI: nan


Zhengguo Xu, Marina Cuquerella-Gilabert, Javier Zarzoso-Foj, Matilde Merino-Sanjuan, Victor Mangas-Sanjuan, Alfredo García-Arieta

Comparison of dissolution profiles: 90% confidence intervals of different f2 estimators using bootstrap methodology versus the Euclidean Distance of the Non-standardized Expected (EDNE) values

European Journal of Pharmaceutics and Biopharmaceutics · DOI: 10.1016/j.ejpb.2025.114839


Elena Godoy-Molina, Natalia L. Serrano, Aquilina Jiménez-González, Victor Mangas-Sanjuan, Francesc Palau

Elesclomol-copper therapy improves neurodevelopment in two children with Menkes disease

The Journal of clinical investigation · DOI: 10.1172/JCI193107


Javier Zarzoso-Foj, Marina Cuquerella-Gilabert, Matilde Merino-Sanjuan, Javier Reig-Lopez, Víctor Mangas-Sanjuán, Alfredo Garcia-Arieta

Physiologically-Based Biopharmaceutics Modeling for Ibuprofen: Identifying Key Formulation Parameter and Virtual Bioequivalence Assessment

Pharmaceutics · DOI: 10.3390/pharmaceutics17040408


Javier Reig-López, Xurxo García-Otero, Marina Cuquerella-Gilabert, Enrique Bandín-Vilar, Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro, Víctor Mangas-Sanjuán, Virginia Merino, Pablo Aguiar, Matilde Merino-Sanjuán

A physiologically based pharmacokinetic model to describe [89Zr]Zr-DFO-Adalimumab specific activity after intravitreal administration to rats with endotoxin-induced uveitis

International Journal of Pharmaceutics · DOI: 10.1016/j.ijpharm.2025.125845


Karine Rodriguez‑Fernandez, José David Gómez‑Mantilla, Suneet Shukla, Peter Stopfer, Peter Sieger, Victor Mangas‑Sanjuán, Sheila Annie Peters

Evaluation of Solubility-Limited Absorption as a Surrogate to Predicting Positive Food Effect of BCS II/IV Drugs

Clinical Pharmacokinetics · DOI: 10.1007/s40262-025-01473-9


Iris M. Domenech-Monsell, Adrián M. Alambiaga-Caravaca, Lucía Bernat-Just, Virginia Merino, Vicent Rodilla, Cristina Balaguer-Fernández & Alicia López-Castellano

Innovative Famciclovir Eye Drop Formulations for Herpes Zoster Infections

Current Eye Research · DOI: 10.1080/02713683.2025.2472363


Karine Rodríguez-Fernández, Javier Zarzoso-Foj, Marina Saez-Bello, Almudena Mateu-Puchades, Antonio Martorell-Calatayud, Matilde Merino-Sanjuan, Elena Gras-Colomer, Monica Climente-Martí, Victor Mangas-Sanjuan

Model-Informed Precision Dosing for Personalized Ustekinumab Treatment in Plaque Psoriasis

Pharmaceutics · DOI: 10.3390/pharmaceutics16101295


Karine Rodriguez-Fernandez, Javier Zarzoso-Foj, Marina Saez-Bello, Almudena Mateu-Puchades, Antonio Martorell-Calatayud, Matilde Merino-Sanjuan, Elena Gras-Colomer, Monica Climente-Marti, Victor Mangas-Sanjuan

Personalized Secukinumab Treatment in Patients with Plaque Psoriasis Using Model-Informed Precision Dosing

Pharmaceutics · DOI: 10.3390/pharmaceutics16121576


Carlos Tamarit-Martínez, Lucía Bernat-Just, Carlos Bueno-López, Adrián M. Alambiaga-Caravaca, Virginia Merino, Alicia López-Castellano, Vicent Rodilla

An Antibacterial-Loaded PLA 3D-Printed Model for Temporary Prosthesis in Arthroplasty Infections: Evaluation of the Impact of Layer Thickness on the Mechanical Strength of a Construct and Drug Release

Pharmaceutics · DOI: 10.3390/pharmaceutics16091151


Andreu Mañez-Asensi, Mª Jesús Hernández, Víctor Mangas-Sanjuán, Ana Salvador, Matilde Merino-Sanjuán, Virginia Merino

Impact of Time on Parameters for Assessing the Microstructure Equivalence of Topical Products: Diclofenac 1% Emulsion as a Case Study

Pharmaceutics · DOI: 10.3390/pharmaceutics16060749


Javier Reig-López, Marina Cuquerella-Gilabert, Enrique Bandín-Vilar,Matilde Merino-Sanjuán, Víctor Mangas-Sanjuán, Alfredo García-Arieta

Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers

European Journal of Pharmaceutics and Biopharmaceutics · DOI: 10.1016/j.ejpb.2024.114293


Gema J. Cabañero-Resta, Bárbara Sánchez-Dengra, Alejandro Ruiz-Picazo, Marival Bermejo, Virginia Merino, Isabel Gonzalez-Alvarez, Marta Gonzalez-Alvarez

Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole

Pharmaceutics · DOI: 10.3390/pharmaceutics16050576


Gloria M. Alfosea-Cuadrado, Javier Zarzoso-Foj, Albert Adell, Alfonso A. Valverde-Navarro, Eva M. González-Soler, Víctor Mangas-Sanjuán, Arantxa Blasco-Serra

Population Pharmacokinetic–Pharmacodynamic Analysis of a Reserpine-Induced Myalgia Model in Rats

Pharmaceutics · DOI: 10.3390/pharmaceutics16081101


Marina Cuquerella-Gilabert, Javier Reig-López, Jenifer Serna, Almudena Rueda-Ferreiro, Matilde Merino-Sanjuan, Victor Mangas-Sanjuan, Sergio Sánchez-Herrero

Phys-DAT: A physiologically-based pharmacokinetic model for unraveling the dissolution, transit and absorption processes using PhysPK®

Computer Methods and Programs in Biomedicine · DOI: 10.1016/j.cmpb.2023.107929


Karine Rodríguez-Fernández, Gledys Reynaldo-Fernández, Stephanie Reyes-González, Camila de las Barreras, Leyanis Rodríguez-Vera, Cornelis Vlaar, Jean-Christophe M. Monbaliu, Torsten Stelzer, Jorge Duconge, Victor Mangas-Sanjuan

New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model

Biomedicine & Pharmacotherapy · DOI: 10.1016/j.biopha.2023.115977


Enrique Bandín-Vilar, Francisco José Toja-Camba, María Vidal-Millares, María José Durán-Maseda, Marta Pou-Álvarez, Ana Castro-Balado, Olalla Maroñas, Almudena Gil-Rodríguez, Ángel Carracedo, Irene Zarra-Ferro, Dolors Soy, Anxo Fernández-Ferreiro, Víctor Mangas-Sanjuan, Cristina Mondelo-García

Towards precision medicine of long-acting aripiprazole through population pharmacokinetic modelling

Psychiatry Research · DOI: 10.1016/j.psychres.2024.115721


Iria Varela-Rey, Enrique Bandín-Vilar, Francisco José Toja-Camba, Antonio Cañizo-Outeiriño, Francisco Cajade-Pascual, Marcos Ortega-Hortas, Víctor Mangas-Sanjuan, Miguel González-Barcia, Irene Zarra-Ferro, Cristina Mondelo-García, Anxo Fernández-Ferreiro

Artificial Intelligence and Machine Learning Applications to Pharmacokinetic Modeling and Dose Prediction of Antibiotics: A Scoping Review

Antibiotics · DOI: 10.3390/antibiotics13121203


Isabel Gonzalez-Alvarez, Alejandro Ruiz-Picazo, Ruben Selles-Talavera, Andres Figueroa-Campos,Virginia Merino, Marival Bermejo, Marta Gonzalez-Alvarez

In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug

Pharmaceutics · DOI: 10.3390/pharmaceutics16030390


Javier Reig-Lopez, Weifeng Tang, Carlos Fernandez-Teruel, Matilde Merino-Sanjuan, Victor Mangas-Sanjuan, David W. Boulton, Pradeep Sharma

Application of population physiologically based pharmacokinetic modelling to optimize target expression and clearance mechanisms of therapeutic monoclonal antibodies

British Journal of Clinical Pharmacology · DOI: 10.1111/bcp.15745


Maria Garcia-Cremades, Zinnia Patricia Parra-Guillen, Victor Mangas-Sanjuan, Hugo Geerts

Editorial: Innovative pharmacometric approaches to inform drug development and clinical use

Frontiers in Pharmacology · DOI: 10.3389/fphar.2023.1274139


Pablo Rodríguez-Belenguer, Eric March-Vila, Manuel Pastor, Victor Mangas-Sanjuan, Emilio Soria-Olivas

Usage of model combination in computational toxicology

Toxicology Letters · DOI: 10.1016/j.toxlet.2023.10.013


Pablo Rodriguez, Victor Mangas-Sanjuan, Emilio Soria Olivas, Manuel Pastor

Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis

Journal of Chemical Information and Modeling · DOI: 10.1021/acs.jcim.3c00945


P. Rodríguez Belenguer, Victor Mangas-Sanjuan, Emilio Soria Olivas, Manuel Pastor

P06-15: Evaluating the impact of molecule properties and structural pharmacokinetic models for predicting cholestasis

Toxicology Letters · DOI: 10.1016/S0378-4274(23)00519-2


Aymara Sancho-Araiz, Zinnia P. Parra-Guillen, Jean Bragard,Sergio Ardanza, Victor Mangas-Sanjuan, Iñaki F. Troco ́ niz

Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment

PLOS Computational Biology · DOI: 10.1371/journal.pcbi.1011507


Víctor Mangas-Sanjuán, Marta Simón, Esperanza González-Rojano, Dolores Ochoa, Francisco Abad-Santos, Manuel Román, Mercedes Ramos, Carlos Govantes, Alfredo García-Arieta

Alternative Pharmacokinetic Metrics in Single-Dose Studies to Ensure Bioequivalence of Prolonged-Release Products at Steady State—A Case Study

Pharmaceutics · DOI: 10.3390/pharmaceutics15020409


Jorge Duconge, Victor Mangas-Sanjuan, Gledys Reynaldo Fernández

Conceptos y aplicaciones de los parámetros farmacocinéticos: Una guía para el salón de clases

Journal of Pharmacy & Pharmacognosy Research · DOI: 10.56499/jppres22.1472_11.1.160


Alfredo García-Arieta, John Gordon, Luther Gwaza, Virginia Merino, Víctor Mangas-Sanjuan

Regulatory Requirements for the Development of Second-Entry Semisolid Topical Products in the European Union

Pharmaceutics · DOI: 10.3390/pharmaceutics15020601


Angélica Villanueva-Martínez, Virginia Merino, Adriana Ganem-Rondero

Transdermal formulations and strategies for the treatment of osteoporosis

Journal of Drug Delivery Science and Technology · DOI: 10.1016/j.jddst.2022.103111


Javier Reig-Lopez, Matilde Merino-Sanjuan, Alfredo García-Arieta, Victor Mangas-Sanjuan

A physiologically based pharmacokinetic model for open acid and lactone forms of atorvastatin and metabolites to assess the drug-gene interaction with SLCO1B1 polymorphisms

Biomedicine & Pharmacotherapy · DOI: 10.1016/j.biopha.2022.113914


Teresa García-Martínez, María Dolores Bellés-Medall, Maria García-Cremades, Raúl Ferrando-Piqueres, Victor Mangas-Sanjuán, Matilde Merino-Sanjuan

Population Pharmacokinetic/Pharmacodynamic Modelling of Daptomycin for Schedule Optimization in Patients with Renal Impairment

Pharmaceutics · DOI: 10.3390/pharmaceutics14102226


Karine Rodríguez-Fernandez, Elena Gras-Colomer, Monica Climente-Martí, Victor Mangas-Sanjuan, Matilde Merino-Sanjuan

Pharmacometric characterization of entero-hepatic circulation processes of orally administered formulations of amiodarone under complex binding kinetics

European Journal of Pharmaceutical Sciences · DOI: 10.1016/j.ejps.2022.106198


Karine Rodríguez-Fernández, Víctor Mangas-Sanjuán, Matilde Merino-Sanjuán, Antonio Martorell-Calatayud, Almudena Mateu-Puchades, Mónica Climente-Martí, Elena Gras-Colomer

Impact of Pharmacokinetic and Pharmacodynamic Properties of Monoclonal Antibodies in the Management of Psoriasis

Pharmaceutics · DOI: 10.3390/pharmaceutics14030654


Enrique Bandín‑Vilar, Laura García‑Quintanilla, Ana Castro‑Balado Irene Zarra‑Ferro1,2 ·Miguel González‑Barcia, Manuel Campos‑Toimil, Víctor Mangas‑Sanjuan, Cristina Mondelo‑García, Anxo Fernández‑Ferreiro

A Review of Population Pharmacokinetic Analyses of Linezolid

Clinical Pharmacokinetics · DOI: 10.1007/s40262-022-01125-2


Mark McAllister, Talia Flanagan, Susan Cole, Andreas Abend, Evangelos Kotzagiorgis, Jobst Limberg,Heather Mead, Victor Mangas-Sanjuan, Paul A. Dickinson, Andrea Moir, Xavier Pepin,Diansong Zhou, Christophe Tistaert, Aristides Dokoumetzidis, Om Anand, Maxime Le Merdy,David B. Turner, Brendan T. Griffin, Adam Darwich, Jennifer Dressman, Claire Mackie

Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

Pharmaceutics · DOI: 10.3390/pharmaceutics14051010


Elena Gras-Colomer, Víctor Mangas-Sanjuán, María-Amparo Martínez-Gomez, Monica Climente-Martí, Matilde Merino-Sanjuan

Quantitative assessment of the exposure–efficacy relationship of glucocerebrosidase using Markovian elements in Gaucher patients treated with enzyme replacement therapy

British Journal of Clinical Pharmacology · DOI: 10.1111/bcp.15198


Aymara Sancho-Araiz, Sara Zalba, María J. Garrido, Pedro Berraondo, Brian Topp,Dinesh de Alwis 5, Zinnia P. Parra-Guillen, Víctor Mangas-Sanjuan, Iñaki F. Trocóniz

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors

Cancers · DOI: 10.3390/cancers13205049


Francisco José Toja-Camba, Nerea Gesto-Antelo, Olalla Maroñas, Eduardo Echarri Arrieta,Irene Zarra-Ferro, Miguel González-Barcia, Enrique Bandín-Vilar, Victor Mangas Sanjuan, Fernando Facal, Manuel Arrojo Romero, Angel Carracedo, Cristina Mondelo-García, Anxo Fernández-Ferreiro

Review of Pharmacokinetics and Pharmacogenetics in Atypical Long-Acting Injectable Antipsychotics

Pharmaceutics · DOI: 10.3390/pharmaceutics13070935


Aymara Sancho-Araiz, Victor Mangas-Sanjuan, Iñaki F Trocóniz

The Role of Mathematical Models in Immuno-Oncology: Challenges and Future Perspectives

Pharmaceutics · DOI: 10.3390/pharmaceutics13071016


Begoña Porta-Oltra, Matilde Merino

Personalized pharmacotherapy in oncology: Application of pharmacokinetic-pharmacodynamic criteria

Farmacia Hospitalaria · DOI: 10.7399/fh.11777


I. Camara-Martinez, J.A. Blechar, A. Ruiz-Picazo, A. Garcia-Arieta, C. Calandria,V. Merino-Sanjuan, P. Langguth, M. Gonzalez-Alvarez, M. Bermejo, J. Al-Gousous, I. Gonzalez-Alvarez

Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen

International Journal of Pharmaceutics · DOI: 10.1016/j.ijpharm.2021.121415


Carlos Bueno-López, Carlos Tamarit-Martínez, Adrián M. Alambiaga-Caravaca, Cristina Balaguer-Fernández, Virginia Merino , Alicia López-Castellano, Vicent Rodilla

3D Printing of Temporary Prostheses for Controlled-Release of Drugs: Design, Physical Characterization and Preliminary Studies

Pharmaceutics · DOI: 10.3390/ph14121240


Adrián M. Alambiaga-Caravaca, Iris M. Domenech-Monsell, María Sebastián-Morelló, M. Aracely Calatayud-Pascual, Virginia Merino, Vicent Rodilla, Alicia López-Castellano

Development, characterization, and ex vivo evaluation of an insert for the ocular administration of progesterone

International Journal of Pharmaceutics · DOI: 10.1016/j.ijpharm.2021.120921


Mayank Singhal, César Serna, Virginia Merino, Yogeshvar N. Kalia

Current profile controlled transdermal delivery of pramipexole from an iontophoretic patch system in vitro and in vivo

European Journal of Pharmaceutics and Biopharmaceutics · DOI: 10.1016/j.ejpb.2021.06.010


Ana Moya-Gil, María Amparo Martínez-Gómez, Begoña Porta-Oltra, Matilde Merino-Sanjuán, Mónica Climente-Martí

Physico-Chemical Stability of Admixtures of Vinflunine Used in Clinical Practice

Journal of Pharmaceutical Sciences · DOI: 10.1016/j.xphs.2021.02.021


Javier Reig López, Alfredo García Arieta, Victor Mangas-Sanjuan, Matilde Merino

Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making

Pharmaceutics · DOI: 10.3390/pharmaceutics13050709


Zhengguo Xu, Matilde Merino, Victor Mangas-Sanjuan, Alfredo García Arieta

Estimators and Confidence Intervals of f 2 Using Bootstrap Methodology for the Comparison of Dissolution Profiles

Computer Methods and Programs in Biomedicine · DOI: 10.1016/j.cmpb.2021.106449


Lucía López-Sánchez, Pablo Miralles, Amparo Salvador, Matilde Merino-Sanjuán, Virginia Merino

In vitro skin penetration of bronidox, bronopol and formaldehyde from cosmetics

Regulatory Toxicology and Pharmacology · DOI: 10.1016/j.yrtph.2021.104888


Zhengguo Xu, Víctor Mangas-Sanjuán, Matilde Merino-Sanjuán,Virginia Merino, Alfredo García-Arieta

Influence of Inter- and Intra-Batch Variability on the Sample Size Required for Demonstration of Equivalent Microstructure of Semisolid Dosage Forms

Pharmaceutics · DOI: 10.3390/pharmaceutics12121159


Valeria Gigante, Giovanni M. Pauletti, Sabine Kopp, Minghze Xu, IsabelGonzalez-Alvarez, Virginia Merino, Michelle P. McIntosh, Anita Wessels, Beom-Jin Lee, Kênnia Rocha Rezende, Gerhard K.E. Scriba, Gaurav P. S. Jadaun, Marival Bermejo

Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system

ADMET & DMPK · DOI: 10.5599/admet.850


Adrian H. Teruel, Isabel Gonzalez-Alvarez, Marival Bermejo, Virginia Merino, Maria Dolores Marcos, Felix Sancenon, Marta Gonzalez-Alvarez, Ramon Martinez-Mañez

New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy

International Journal of Molecular Sciences (IJMS) · DOI: 10.3390/ijms21186502


Andrés Figueroa-Campos, Bárbara Sánchez-Dengra, Virginia Merino, Arik Dahan, Isabel González-Álvarez, Alfredo García-Arieta , Marta González-Álvarez, Marival Bermejo

Candesartan Cilexetil In Vitro–In Vivo Correlation: Predictive Dissolution as a Development Tool

Pharmaceutics · DOI: 10.3390/pharmaceutics12070633


Jordi Ocaña, Toni Monleón-Getino, Virginia Merino, Daniel Peris, Lluís Soler

Statistical Methods for Quality Equivalence of Topical Products. 0.5 mg/g Betamethasone Ointment as a Case-Study

Pharmaceutics · DOI: 10.3390/pharmaceutics12040318


Javier Reig-López, María del Mar Maldonado, Matilde Merino-Sanjuan, Ailed M. Cruz-Collazo, Jean F. Ruiz-Calderón, Victor Mangas-Sanjuán, Suranganie Dharmawardhane, Jorge Duconge

Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice

Pharmaceutics · DOI: 10.3390/pharmaceutics12100975


Marina Sáez-Belló, Víctor Mangas-Sanjuán, Mª. Amparo Martínez-Gómez, Mª. Angeles López-Montenegro Soria, Mónica Climente-Martí, Matilde Merino-Sanjuán

Evaluation of ABC gene polymorphisms on the pharmacokinetics and pharmacodynamics of capecitabine in colorectal patients: Implications for dosing recommendations

British Journal of Clinical Pharmacology · DOI: 10.1111/bcp.14441


Elena Gras Colomer, Victor Mangas-Sanjuan, Monica Climente, Matilde Merino

Population pharmacokinetic of enzymatic activity of glucocerebrosidase in Gaucher disease patients treated with enzyme replacement therapy

Molecular Genetics and Metabolism · DOI: 10.1016/j.ymgme.2019.11.160


Javier Reig López, Matilde Merino, Victor Mangas-Sanjuan, Manuel Prado-Velasco

A Multilevel Object-Oriented Modelling Methodology for Physiologically-Based Pharmacokinetics (PBPK): Evaluation with a Semi-Mechanistic Pharmacokinetic Model

Computer Methods and Programs in Biomedicine · DOI: 10.1016/j.cmpb.2020.105322


Darlene Santiago, Victor Mangas-Sanjuan, Kyle Melin, Jorge Duconge, Wenchen Zhao, Raman Venkataramanan

Pharmacokinetic Characterization and External Evaluation of a Quantitative Framework of Sublingual Buprenorphine in Patients with an Opioid Disorder in Puerto Rico

Pharmaceutics · DOI: 10.3390/pharmaceutics12121226


Niurys de Castro-Suárez, Mirjam N. Trame, Mayra Ramos-Suzarte, José M. Dávalos, Raymed A. Bacallao-Mendez, Anaelys R. Maceo-Sinabele, Víctor Mangas-Sanjuán, Gledys Reynaldo-Fernández, Leyanis Rodríguez-Vera

Semi-Mechanistic Pharmacokinetic Model to Guide the Dose Selection of Nimotuzumab in Patients with Autosomal Dominant Polycystic Kidney Disease

Pharmaceutics · DOI: 10.3390/pharmaceutics12121147


Sotirios Michaleas , Elisabeth Penninga , Doris Hovgaard , Anne‐Marie Dalseg , Aldana Rosso , Sinan B. Sarac , Jorge Camarero Jimenez , Lucia López‐Anglada Fernández , Carolina Prieto Fernández , Victor Mangas‐SanJuan

The European Medicines Agency review of daratumumab (Darzalex) for the treatment of adult patients newly diagnosed with multiple myeloma

The Oncologist · DOI: 10.1002/onco.13554


Stephanie Reyes-González , Camila de las Barreras , Gledys Reynaldo , Leyanis Rodríguez-Vera , Cornelis Vlaar , Vilmali Lopez Mejias , Jean-Christophe M. Monbaliu , Torsten Stelzer , Victor Mangas and Jorge Duconge

Genotype-driven pharmacokinetic simulations of warfarin levels in Puerto Ricans

Drug Metabolism and Personalized Therapy · DOI: 10.1515/dmdi-2020-0135


Lucas Noce, Luther Gwaza, Victor Mangas-Sanjuan, Alfredo García Arieta

Comparison of free software platforms for the calculation of the 90% confidence interval of f2 similarity factor by bootstrap analysis

European Journal of Pharmaceutical Sciences · DOI: 10.1016/j.ejps.2020.105259


Patents

  • 2018
  • 2016

Sistema de Liberación Controlada y Método de Preparación del Mismo. P201830512. Universitat Politècnica de València (UPV); Universitat de València (UV); Universidad Miguel Hernández (UMH).

H Teruel, Adrián; Martínez-Máñez, Ramón; Sancenón Galarza, Félix; VIRGINIA MERINO SANJUÁN.


Formulación para liberación modificada de sustancias activas o fármacos, uso y procedimiento de obtención. P201631463. Universidad Miguel Hernández (UMH); Universitat de València (UV); Consejo Superior de Investigaciones Científicas (CSIC); Universitat Politècnica de València (UPV).

Martínez-Martínez MT; González-Álvarez M; Bermejo-Sanz MV; Rodríguez-Berna G; Corma-Canós A; Merino- Sanjuán V.


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